Synthesis of Transition Metal Complexes of Isoniazid Derivatives and Urease Inhibition Activity Detection

Abstract: It have been reported that the transition metal complex of Schiff base ligands ability to inhibit urease. Herein, in this manuscript, two novel complexes [Cd2(L)2·(H2O)] (1), [Pb(L)·, [Pbe2) were synthesized based on chelating hydrazone ligand N‘-(pyridin-2-ylmethylene)isonicotinohydrazide (L). These compounds tested by single crystal X-ray diffraction and determined structure for urease resistance vitro. The 2 exhibited better activities inhibiting than positive control acetohydroxamic acid with an IC50 =2.5 μM, while 1 showed weak activity, acted as effective inhibitor. Key words: Cadmium(II) complexes, Plumbum(II) Crystal structure, base, Urease